Mashhad University of medical sciences Mashhad Iran CD23, the low affinity receptor for IgE (FCε R II), functions as a multifunctional regulator of immune system and IgE synthesis, in part, by producing an IgE binding factor (soluble CD23). Objectives: To evaluate the serum levels of total IgE and soluble CD23 (sCD23) in the atopic patients and to determine whether there is any correlation between these markers. Method: Forty-five adult atopic subjects (allergic rhinitis 17, allergic asthma 17 and atopi dermatitis 11) with positive skin prick test to common allergens and positive family history of atopy were entrolled in a case-control study. Serum levels of total IgE and sCd23 of these subjects were measured by ELISA controls. Results: Mean age and sex ratio were similar among study groups. Mean serum levels of sCD23 in atopic groups (5.12±3.9ng/ml) were significantly higher than control group (0.2ng/ml) (P<0.01). Mean total IgE level in atopic groups and control group were 388±204 IU/ml, 43±40 IU/ml respectively. Atopic subjects had significantly higher IgE level (P<0.01). There were no correlations between serum levels of total IgE and sCD23. Conclusion: sCD23 maybe a good atopy prediction marker. 

Determining the normal range of Immunoglobulin E (IgE) in any population is important for diagnosis of allergic diseases. The aim of this study was to determine normal values of IgE in children living in Tehran. Two-handed and fifty six healthy children aged one month to 14 years were selected. These children had neither parasitic infections nor atopic disease. They were divided into six groups and the total serum IgE levels were measured by ELISA methods. The references range of the IgE levels were 0.1-25, 0.8-162, 0.6-184, 3-221, 2.9-501 and 2-316 KU/L in age groups as follows: <3 month, 4-12 months, 1-3, 3-7, 7-10, and 10-14 years respectively. IgE levels were higher in boys but were not statistically significant except in 4-12-month olds (P<0.005). There was also an increase in IgE levels with age. Normal value of serum total IgE obtained in this study could be useful to contribute for diagnosis of allergic disease, as reference ranges in Iranian healthy children.

Background: Total serum IgE measurement and skin prick tests are the most common tools for allergy diagnosis. This investigation was conducted to evaluate total serum IgE and skin prick test relationship in Iranian atopic children with respiratory manifestations. Materials and Methods: A history of allergic rhinitis, bronchial asthma and atopic dermatitis was obtained in 232 children (aged 1 to 15 years). Skin prick testing was performed using commercial preparation of the common allergens. The patients' sera were also analyzed for determining total IgE. Results: More than 95% (n=221) of the patients had positive skin prick test (mean wheal diameter  ³3mm) to one allergen or more. Among the patients 46% (n=107) had elevated total serum lgE levels (³150 lU/ml). Conclusion: The study showed close relationship of skin test positivity with reported allergic symptoms, but no correlation was found between total IgE and skin prick test. This study revealed that skin testing and total serum IgE measurement may be considered complementary to one another in diagnosing allergic respiratory disorders.

Psoriasis is a chronic relapsing disorder that involves the skin, nails and joints. With regard to the role of the immune system in psoriasis, the current study compared serum IgE concentration in patients with psoriasis with control group. Current case-control study was conducted in Dermatology clinic of Razi hospital, Tehran University of medical sciences, Tehran, Iran in 2012. Fifty-eight patients with psoriasis e referred to the clinic were assigned as patient group and 58 healthy subjects with matched age and sex as a control group. Patient's history, family history and demographic characteristics such as age and sex, duration and severity of disease using PASI, were collected and entered into a form. Consent form was obtained from participants. Serum IgE concentrations of both study groups were measured by electrochemiluminescence assay in the laboratory A total number of 58 patients with psoriasis, mean age of 44.15 (19-76 years) and 58 controls with matched age and sex were studied. Mean average of serum IgE concentration in the control group was 115.13 versus 200.06 concentration in patients group (P=0.16). Serum IgE concentration in 22.4% of patients versus 17.2% in controls was greater than normal concentration (P=0.48). No significant correlation was between serum IgE concentration and disease severity using PASI (P=0.11, r=0.21), neither a significant correlation with disease duration, age and gender. According to the present study, serum IgE concentrations are not greater in patients with psoriasis. IgE concentration is also not associated with the severity of psoriasis based on the PASI score, therefore, the role of IgE in psoriasis can be considered insignificant as some previous studies indicate.